venofer dosing calculator venofer dosing calculator

Applies only to oral form of both agents. Minor/Significance Unknown. World J Gastroenterol; 16(22): 27202725. May increase risk of hypotension. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet Administration: I. Immune system disorders: Anaphylactic-type reactions, angioedema, Nervous system disorders: Convulsions, collapse, light-headedness, loss-of-consciousness, Respiratory, thoracic and mediastinal disorders: Bronchospasm, dyspnea, Musculoskeletal and connective tissue disorders: Back pain, swelling of the joints, General disorders and administration site conditions: Hyperhidrosis, Published studies on intravenous iron sucrose treatment after first trimester of pregnancy not shown adverse maternal or fetal outcomes; available reports of intravenous iron sucrose use in pregnant women during first trimester are insufficient to assess risk of major birth defects and miscarriage; iron deficiency anemia during pregnancy should be treated because there are risks to mother and fetus associated with untreated iron deficiency anemia (IDA) in pregnancy; risks to fetus associated with maternal severe hypersensitivity reactions, Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products which may cause fetal bradycardia, especially during second and third trimester, Iron sucrose is present in human milk, and available published reports following exposure to 100-300 mg intravenous iron sucrose have not reported adverse reactions in breastfed infants; there are no data on effects on milk production, Developmental and health benefits of breastfeeding should be considered, along with mothers clinical need for treatment and any potential adverse effects on breastfed child from therapy or from underlying maternal condition. Minor (1)gymnema decreases levels of iron sucrose by inhibition of GI absorption. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. 1996 Aug;11(4):139-46. Ren Fail. The primary endpoint was the proportion of patients with . Use Caution/Monitor. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown. Use Caution/Monitor. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. Elemental iron product this is a choice between three iron supplement products: Iron dextran 50 mg/mL, Iron sucrose 20 mg/mL and Ferric gluconate 12.5 mg/mL. iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Use Caution/Monitor. Avoid or Use Alternate Drug. Administer Venofer early during the dialysis session (generally within the first hour). Applies only to oral form of both agents. PRECAUTIONS: Before using iron sucrose, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Accessed: 4/12/2011. Avoid or Use Alternate Drug. Applies only to oral form of both agents. 1. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. Medicinal forms Transferrin saturation (TSAT) values increase rapidly after intravenous administration of iron sucrose; do not perform serum iron measurements for at least 48 hours after intravenous dosing. Contact the applicable plan Applies only to oral form of both agents. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . 1 ,*. Applies only to oral form of both agents. Interaction only with oral iron administration. Venofer treatment may be repeated if necessary. Feraheme does not contain antimicrobial preservatives. By clicking send, you acknowledge that you have permission to email the recipient with this information. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Do Not Copy, Distribute or otherwise Disseminate without express permission. Fatal reactions have followed the test dose of iron dextran injection. Adverse pregnancy outcomes associated with IDA include increased risk for preterm delivery and low birth weight. Individual plans may vary J Med. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. Properly discard this product when it is expired or no longer needed. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. Med J Aust. Where C= concentration of Applies only to oral form of both agents. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. Iron Deficiency In Pregnancy Calculator, Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator. Venofer treatment may be repeated if necessary. 1970;100(7):301303. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Adult Patients: The most common adverse reactions (2%) include diarrhea, nausea, vomiting, headache, dizziness, hypotension, pruritus, pain in extremity, arthralgia, back pain, muscle cramp, injection site reactions, chest pain and peripheral edema. Each mL contains 20 mg of elemental . calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. During all INFeD administrations, observe for signs or symptoms of anaphylactic-type reactions. Use Caution/Monitor. VENOFER at IV doses up to 15 mg iron/kg/dose [about 10 times the maximum recommended human dose for a 70 kg person] given three times a week was found to have no effect on fertility . The therapeutic management of IDA focuses on the replenishment of the iron stores through methods that have been mentioned above. Applies only to oral form of both agents. A patients lean body weight (or actual body weight if less than lean body weight) should be utilized when determining dosage. There is in depth information below the form on the method used and on the result provided. Before using, check this product visually for particles or discoloration. Minor/Significance Unknown. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Calculosaurus | Medical calculators for obstetrics and gynaecology Use the menu to browse through our clinical calculators. Minor/Significance Unknown. Administer iron products at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. In the text below the tool there is more information on how the iron deficit is calculated. For additional Safety Information, please see Full Prescribing Information. Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl over a period of 15 minutes. Applies only to oral form of both agents. Applies only to oral form of both agents. This parenteral iron replacement for iron deficiency anemia calculator determines the parenteral dose of iron supplement needed to replenish iron stores and hemoglobin levels. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Venofer may reduce the absorption of concomitantly administered oral iron preparations. This drug is available at the lowest co-pay. Applies only to oral form of both agents. Access your plan list on any device mobile or desktop. 2. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Use Caution/Monitor. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. commonly, these are generic drugs. ANNA J. Safety of highdose iron sucrose infusion in hospitalized patients with chronic kidney disease. Avoid or Use Alternate Drug. Kumpf VJ, Holland EG. Applies only to oral form of both agents. The iron deficit calculator is useful as one of the determinations performed before iron replenishment therapy is initiated. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 - Hb in g/dL) x 2.145 Volume of product required in mL = Iron deficit in mg / C in mg/mL Where C is the concentration of the iron product: 50 mg/mL for Iron dextran; 20 mg/mL for Iron sucrose; 5 mg/mL for Ferric gluconate. Applies only to oral form of both agents. Applies only to oral form of both agents. After total replacement dose completed, need for ongoing IV doses should be re-assessed monthly. Iron deficiency anemia is the type of anemia caused by iron depletion. Calculates iron deficit for dosing iron. Deferoxamine chelates iron. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. All Rights Reserved. Share cases and questions with Physicians on Medscape consult. * Calculators are available in UpToDate to determine ideal body weight and lean body weight. Minor/Significance Unknown.iron sucrose increases levels of calcium citrate by enhancing GI absorption. Corrected Sodium and Effective Osmolality. For patients weighing less than 50 kg (110 lb): Give Injectafer in two doses separated by at least 7 days. an automated flowchart approach. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). In post-marketing safety studies of Venofer in 1,051 patients with HDD-CKD, adverse reactions reported by >1% were cardiac failure congestive, sepsis and dysgeusia. Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Adult Patients with Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD): Administer Venofer 200 mg undiluted as a slow intravenous injection over 2 to 5 minutes or as an infusion of 200 mg in a maximum of 100 mL of 0.9% NaCl x 15 minutes. This information is not individual medical advice and does not substitute for the advice of your health care professional. Applies only to oral form of both agents. Each mL contains 20 mg of elemental iron. 2.1 Dosage - Total dose infusion The dose calculation for CosmoFer is based on patients body weight according to the table below and is diluted in 500mLs of normal saline. Applies only to oral form of both agents. Venofer has not been studied in patients younger than 2 years old. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Applies only to oral form of both agents. USES: This medicine is used to treat "iron-poor" blood (anemia) in people with long-term kidney disease. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. Anemia. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Serious - Use Alternative (1)iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Although the original formula requires the weight in kilograms, values input in lbs are transformed. Applies only to oral form of both agents. A: Generally acceptable. iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. David McAuley, Pharm.D. By using this form you agree with the storage and handling of your data by this website. ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. Minor (1)iron sucrose, captopril. Applies only to oral form of both agents. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Applies only to oral form of both agents. 2 DOSAGE & ADMINISTRATION Venofer must only be administered intravenously either by slow injection or by infusion. Human studies not conducted. Parenteral iron dextran therapy: a review. iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. . 4. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. This product may contain inactive ingredients, which can cause allergic reactions or other problems. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. The recommendation is that most adults need a cumulative dose of elemental iron of at least 1 g. Iron replenishment can be done intravenously, either as total dose (example: iron-dextran or iron carboxymaltose) or as split dose (example: iron sucrose). Divide the calculated dose by the patient's weight (IBW if BMI >30, or actual body weight (ABW) if BMI30) to ensure it does NOT exceed 20mg/kg. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); Applies only to oral form of both agents. Use Caution/Monitor. Intravenous Injection - PRIOR TO THE FIRST INTRAVENOUS INFeD THERAPEUTIC DOSE, ADMINISTER AN INTRAVENOUS TEST DOSE OF 0.5 ML. Avoid or Use Alternate Drug. Pediatric Patients (2 Years of Age and Older). calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Observed Hb = the patients current hemoglobin in g/dl. Calcs that help predict probability of a disease, Subcategory of 'Diagnosis' designed to be very sensitive, Disease is diagnosed: prognosticate to guide treatment. This topic . Applies only to oral form of both agents. Applies only to oral form of both agents. Initial infusion rate. Parenteral iron supplementation. Dosing Administration & Considerations . The original formula employs the weight in kg but users can input it in lbs and it gets transformed. May increase risk of hypotension. Minor (2)calcium citrate decreases levels of iron sucrose by inhibition of GI absorption. These adverse reactions have occurred up to 30 minutes after the administration of Venofer injection. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Applies only to oral form of both agents. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Crown Rump Length and Nuchal Translucency. Applies only to oral form of both agents. Use Caution/Monitor. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Medscape Education, Improving Quality of Care in Patients With Iron Deficiency Anemia and Inflammatory Bowel Disease, 2010feosol-carbonyl-fe-icar-c-carbonyl-iron-342171Drugs, encoded search term (iron sucrose (Venofer)) and iron sucrose (Venofer), Use of High-Dose Iron in Dialysis in US Tracks PIVOTAL Trial, FDA Watch List Adds Drugs With Anaphylaxis, Herpes, Fetal Death Risk, Dialysis Industry Mergers: Profits Rise as Patient Outcomes Worsen, Hematology-Oncology Guidelines: 2017 Midyear Review. The dosing of Monofer was performed according to the Simplified Table as described in section 4.2 above and dosing of iron sucrose was calculated according to Ganzoni and administered as 200 mg infusions. Hollands J, Foote E, Rodriguez A. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . For all products, slow initial infusion is prudent; the patient is observed closely for infusion reactions. Available for Android and iOS devices. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Consult your pharmacist or local waste disposal company. Applies only to oral form of both agents. Venofer and the Venofer logo are registered trademarks of Vifor (International) Inc., Switzerland. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. sodium sulfate/?magnesium sulfate/potassium chloride decreases levels of iron sucrose by inhibition of GI absorption. Copyright 2021 GlobalRPH - Web Development by. Use Caution/Monitor. Multiple placebo-controlled, randomized clinical trials have been conducted with IV iron in patients with New York Heart Association class II-III heart failure with an ejection fraction 45% who met criteria . Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Methods: We reviewed the experience of our department between January, 2011 and February, 2014 with the use of intravenous iron sucrose in children 14 years of age who failed in oral iron therapy for iron deficiency anemia (IDA). Applies only to oral form of both agents. Avoid or Use Alternate Drug. May increase risk of hypotension. If we don't have the calculator you need then tell us the details and we'll make it for you. Patients diagnosed with iron deficiency are prescribed iron supplementation, either to replete body stores or to correct anemia. official version of the modified score here. This website also contains material copyrighted by 3rd parties. Avoid or Use Alternate Drug. elemental iron (mg/ml) in the product being used: Where C= Avoid or Use Alternate Drug. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. Included in the iron dextran package insert. Applies only to oral form of both agents. 2.1 . 1 Dosing for patients who weigh less than 50 kg For liquid medications, also enter the value of the Medicine Concentration and choose . Pain, swelling, or redness at the injection site may occur. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Patients may present with shock, clinically significant hypotension, loss of consciousness and/or collapse. 4. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. 1974 Jun;31(6):592-5. Option 2: 200 mg in NS 100 mL administered over 20-30 minutes; may repeat every other day to Applies to didanosine chewable tablets and powder for oral solution; administer 2 hr before or several hours after didanosine oral solution or chewable tablet administration. Separate dosing of tetracyclines from these products. We'll do this entirely for free, as long as the calculator has applications for women's health. Dosing for patients who weigh 50 kg or more For patients weighing 50 kg (110 lb) or more: Give Injectafer in two doses separated by at least 7 days. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. The normal ranges are: for males 13.8 to 18.0 g/dL (138 to 180 g/L, or 8.56 to 11.17mmol/L) and for females 12.1 to 15.1 g/dL (121 to 151 g/L, or 7.51 to 9.37mmol/L). iron sucrose decreases levels of methyldopa by inhibition of GI absorption. Kumpf VJ. May increase risk of hypotension. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Each costs about $0.46 to $0.55 per mg of iron. ADMINISTER THE TEST DOSE AT A GRADUAL RATE OVER AT LEAST 30 SECONDS. in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Administer Venofer early during the dialysis session (generally within the first hour). Use Caution/Monitor. prescription products. iron sucrose decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Adults and Children over 15 kg (33 lbs): Dose (mL) = 0.0442 (Desired Hb - Observed Hb) x LBW + (0.26 x LBW), Desired Hb = the target Hb in g/dl. This site contains information for licensed healthcare professionals in the United States. Applies only to oral form of both agents. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Data from Ferrlecit postmarketing spontaneous reports indicate that individual doses exceeding 125 mg may be associated with a higher incidence and/or severity of adverse events. Do not administer Venofer to patients with iron overload. View the formulary and any restrictions for each plan. Applies only to oral form of both agents. 2 DOSAGE AND ADMINISTRATION 2.1 Recommended Dosage Recommended dosage for patients weighing 50kg (110lb) or more: Give Injectaferin two doses separated by at least 7 days. Equations used: 1] Calculation of the Total Iron Deficit: Total iron deficit [mg] = body weight [kg] x (target Hb-actual Hb) [g/dl] x 2.4 + depot iron [mg].