%PDF-1.3 <> Manufactured by: China . . J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA Cu:3(]N"AQdUt~h|P X\o^ l~5C 5 0 obj The METHOCEL Premium family of water-soluble polymers for pharmaceutical applications offers exceptional flexibility and a broad range of properties typically not found in other water-soluble polymers. Avicel co-processed grades are co-spray dried blends of Avicel microcrystalline cellulose with synergistic pharmaceutical excipients to yield functional benefits beyond simple physical blends. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. 1. MATERIAL SAFETY DATA SHEET. MSDS Ref. endobj Avicel Microcrystalline Cellulose: Chemical Identifiers. Superior Performance: Provides excellent water uptake and rapid swelling . Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. In roller compaction, Avicel Microcrystalline cellulose improves compaction during the ribbon phase, enabling a trouble-free process while also preserving the plasticity of the compacts. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. Chemical Formula: (C6H10O5)n 1.4. ChemicalBook. Molecular weight: Not Applicable 1.5. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. /Contents 4 0 R Various Gelcarin and Viscarin carrageenan grades are used by the pharmaceutical industry to achieve specific gelling for controlled drug release, thickening, and stabilizing properties desired in various formulations. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . Product Name Cellulose microcrystalline. endstream >> This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. Protect them from sunshine or rain. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . It is, however, a good source of fibre. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. It should be noted that native cellulose itself is completely indigestible, and its hydrolysis during the production of microcrystalline cellulose does not alter its behaviour in the intestine. stream ECOLOGICAL INFORMATION ECOTOXICITY Practically nontoxic to fish: Rainbow trout LC50 (96hr) > 100%, saturated solution (Microcrystalline cellulose, Avicel PH-101) PERSISTENCE AND BIODEGRADABILITY Inherently biodegradable. : 5. Micro Crystalline Cellulose. }o]X4]. These grades have particle sizes ranging from <30 to approximately 200. F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. For this reason, nutritionists regard standard powdered microcrystalline cellulose as having zero energy content. Are you sure you want to delete your template? Cellulose is a linear polymer of -D-glucose, linked through carbon atoms 1 and 4. /Parent 3 0 R endobj In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Created Date: 2/10/2020 8:51:41 PM . The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. The fumarate moiety of Alubra increases its melting temperature, which allows for greater functionality at high press speeds while the stearate chain maintains the lubricity of the compound and supports low ejection forces. Magazine: Material safety data sheet - FMC Corporation. The figure below illustrates the structural organisation of cellulose within plants. It is widely used within the pharmaceutical, food, and cosmetic sectors as a formulation aid. SUBSTANCE IDENTIFICATION 1.1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING 1.1 Product identifiers Product name : Avicel PH-101 Product Number : 11365 Brand : Fluka CAS-No. Microcrystalline Cellulose NF. /Type/Page Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. Terms and Conditions Compliance Solutions Industries About 3E News & Events . To meet their exacting standards, we deliver a wide choice of relevant solutions that are simultaneously replicable, scalable and high performing. Doses up to 30 g per day appear to be . IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. High performance lubricant that brings more to the tablet. "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. CAS #: 9004-34-6 1.6. PDF (4.11 mb) Footer menu 1. The cellulose molecule is formed through repeated condensation of cellobiose units. No: 9004-34-6-5 Version: Global Date Approved: 10/16/1998 . Combines good flow and high compactibility. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Description: Microcrystalline Cellulose is a term for refined wood pulp manufactured through plant fibre hydrolysis. CAS #: 9004-34-6 AVICEL RC 581. xv}O2' H~KEe9>G/,:9\i Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . Page 1 of 8. } !1AQa"q2#BR$3br %PDF-1.5 It is made from purified partially depolymerised Alfa cellulose relatively free from both organic and inorganic contaminants. Avicel PC 611 (FMC Biopolymer) Supplied by. lH5JWy}DgKRR"Fs GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. Chemical Formula: (C6H10O5)n 1.4. 1.3. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? : CL-611NF Date Approved: 01/13/2010. Microcrystalline Cellulose Side Effects. Millipore. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. (Microcrystalline Cellulose Market Pr. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Material Safety Data Sheet or SDS for Microcrystalline cellulose 9004-34-6 from chemicalbook for download or viewing in the browser. They are soluble in a wide range of organic solvents, beginning with aliphatic alcohols such as ethanol and isopropanol, and are compatible with most other familiar organic solvent chemistries, including ether alcohols, ketones, aromatic hydrocarbons and many more. The aqueous solution to barrier membrane coating. Document(s): certificate data msds. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. Instead, they obtained a stable colloidal suspension. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. This extends the funcionality of microcrystalline cellulose to meet specific viscosity, gelling, suspension and stabilizing properties ChemPoint is an approved supplier of LATTICE MCC in industrial applications, providing dedicated marketing, sales, order fulfillment, and technical support for customers in the EMEA region, Protect and improve AI potency, entrap oil droplets and improve stability, physical barrier that helps suspend particles and breaks down under shear and reforms quickly under rest. stream Safety Data Sheet for Cellulose microcrystalline 102331. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.) Microcrystalline cellulose -The oldest polymer finds new industrial uses,. It is also used in plaque assays for counting. It is available in different grades and particle sizes. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> Avicel PH-101. The global microcrystalline cellulose (MCC) market was valued at $401.1 million in 2021, and is projected to reach $712.9 million by 2031, growing at a CAGR of 5.9% from 2022 to 2031. FMC, JRS and Mingtai were estimated to hold for . . >> No. Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127. << Have an order or account question? Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named 'mechanically disintegrated D.P cellulose. % There may be more fiber in your food than you realized. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Eur., JPE . Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. ;(Imu9Jv_ YhnHTbwP*:mg"T{BO;!QR e,cqO! << They are white to off-white, free-flowing hydrophilic powders supplied in a variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to 7,000,000 daltons. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . : 9004-34-6 1.2 Relevant identified uses of the substance or mixture and uses advised against However, consumption of large quantities of the material may have a laxative effect. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. Product Name: Microcrystalline Cellulose E460 1.2. Are you looking for information about products and services by region? XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. Cellulose, microcrystalline | C14H26O11 | CID 14055602 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological . ( stream Hi, let us know if you have any questions as you visit our website. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. <> Avicel Microcrystalline Cellulose Physical Properties. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Microcrystalline Cellulose (MCC) MSDS 1. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. Go to Investor Relations. Delivering efficient and robust formulations. Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. However, if handling bulk powders, observance of appropriate safeguards is recommended. EMCOCEL 90 M. 130. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Gloves, eye protection and a dust mask should be used. };khd5x=fr Wu, K. Zuurman, H.W. We can send by Fedex, by ship or by plane according to international rules. Dyvo5bp#bR W7~IF C" d6zLz~!#>@HO}sx;hm>> It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. PDF (28.38 mb) 2022 Corporate Fact Sheet. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . Quick Links. Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge We respect your privacy FMC Privacy Policy. Home. < gV2@o2s&WS@Et%Up:`U '_ h?8qyP=&> GFprm9A!uu1 }&*kQ c^&eX}^K}h9YCb2L(yL):,+g8_u. BIOACCUMULATIVE POTENTIAL X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe Fiber supplements can lessen the absorption of some . TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. 9,LL!z ( The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. Watch Now. Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER ETHOCEL premium ethylcellulose resins are water-insoluble polymers. 0.25 - 0.37. q86@on$^X_HuH;3` 3 0 obj The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. Validity Area. q9;v80q>jZ Microcrystalline cellulose in certain fiber supplements may cause mild side effects ().These may include gas, bloating and increased stool production.. . 2 0 obj These co-processed products are designed to solve complex formulation problems, simplify manufacturing processes, and deliver significant cost savings. Explore how you can develop your career and bring your creative ideas to life at IFF. Biologicals by FMC. 1 0 obj AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? ( microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. Production of Pharmaceutical Grade Microcrystalline Cellulose. We know that our customers need to provide reliable and consistent products to their patients. (AEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEM %)piQpFNnFu\4m4( ESE;m& %QL((((((((((((((((((((((((((((((((((((((((P3NhC Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). Material safety data sheet - FMC Corporation. %PDF-1.4 Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/MediaBox[ 0 0 612 792] /Contents 6 0 R/Group<>/Tabs/S>> 6 0 obj JFIF ` ` ZExif MM * J Q Q Q C Battista, O. From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. <> ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" SCMm_>x^O9l (n. A family of polysaccharide products that allow distinctive drug delivery solutions. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Kristensen, T. Schfer, P. Kleinebudde, Direct pelletization in a rotary processor controlled by torque measurements. We are artists at heart and creators by nature. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. . All Rights Reserved. Burger King, McDonald's and other fast food companies list in the ingredients of several of their foods, microcrystalline cellulose (MCC . Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. 2008-2023 ChemPoint. SUBSTANCE IDENTIFICATION 1.1. Find answers in our support articles. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. (1962). \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! Avicel is a brand name by Dupont for grades of Microcrystalline cellulose. 0.25 - 0.37. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. 1 0 obj Microcrystalline cellulose (MCC) is the most commonly used spheronizing aid in a formulation undergoing extrusion spheronization. ?t#_n|z%4n#(!:lMD~{mfvv}Na0vx?? 4 0 obj The data shown below apply only to Avicel PH 101. Request media, explore upcoming events and read our latest updates. 8 0 obj *r_ *?~4$ &0Y# PDF (2.77 mb) 2021 FMC Sustainability Report. Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Although the breakup of cellulose to form colloidal microcrystalline cellulose has no impact on calorific content of the material, colloidal microcrystalline cellulose contain soluble components (hydrocolloids) that are introduced during processing, which add calories to the product. Packaging: 34 x 50 kgs fiber drums. Microcrystalline Cellulose. ). Have an order or account question, find answers in our Online Support articles. 2021 Annual Report. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Report Category. MATERIAL SAFETY DATA SHEET Version: 1.0 1. % Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. (&E. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. 1.3. 4. q9;v80 stream % Researcher's newest research report, the "Wood Pulp Based Microcrystalline Cellulose Industry Forecast" looks at past sales and reviews total world Wood Pulp Based Microcrystalline Cellulose sales in 2022, providing a comprehensive analysis by region and market sector of . The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. The smallest units, the elementary fibrils (cellulose crystalline strands) are made up of many -(1-4) glucose chains which are bundled to form microfibrils. Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Aqueous suspensions of microcrystalline cellulose have . Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Test Data Available. The typical mean particle size is 20200 m. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . %PDF-1.4 CAS #: 9004-34-6 . gwf;J(e0o|1p{R~P^);ao!%{0KD7. Some substance identifiers may have been claimed confidential, or may . CAS No. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. /MediaBox [0 0 612 792] The UK Health & Safety Executive has set workplace exposure limits at 10 mg/m3 long-term (8 hr TWA) for total inhaled dust and 4 mg/m3 for respirable dust. In 1964 FMC, Corporation . Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents. Date Approved: 05/25/2010. Cellulose microcrystalline for column chromatography. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ? LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. It is . The most. pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ All rights reserved. Microcrystalline Cellulose / Avicel PH-102. The application areas for Avicel Microcrystalline cellulose are immense and encompass many industrial sectors such as food, pharmaceuticals, and cosmetics. stream Watch Now. <> vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? The product range encompasses methylcellulose and hydroxypropyl methylcellulose (hypromellose) each available in different grades to address a wide range of applications including tablet coatings, granulation, controlled release, drug layering, vegetarian hard-shell capsules and amorphous drug stabilization. : 51395-75-6 Date Approved: 01/31/2008 Revision No. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. Microcrystalline cellulose (MCC) for industrial purposes is usually obtained from wood pulp and purified cotton linters. common form is used in vitamin supplements or tablets. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. HMo@9, U Q!R/1*;` )rFHVNzNaJlIo$5ZH(`8Z>s'$UVVWUyD+[t? No. . : 1. Avicel Microcrystalline cellulose is available in many grades, which differ in particle size, bulk density, and moisture content. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Van Veen, G.K. Bolhuis, Y.S. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. zW0} kAmS AYiy QJVWwi ED`52u-I~_ViT3+3kIT D2/A5vP5MHt(*vCBZ5UALFS0Mr v6t3dDda!03O$V>S6n| 3Fz. These, in turn, are assembled into fibrils in the cell wall. B;vLZpHU%ChUyD+[ Your file is uploaded and ready to be published. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Learn about FMC's differentiated biologically-based crop solutions. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Medium size standard MCC grade, suited for the majority of directly compressible actives. METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe.